From the Creator of Interconnected
The Root Cause Revolution:
What Your Gut Is Actually Telling You
Dr. Pedram Shojai's deep-dive masterclass on the functional medicine science of gut health — endotoxemia, the gut-brain axis, precision microbiome medicine, and the 6R Protocol that changes everything.
NYT Bestselling Author
8 Books · 12 Documentary Series
Your Host
Dr. Pedram Shojai
Dr. Shojai ran multi-specialty integrative medicine clinics for over a decade, consulted with 1,400+ companies on corporate wellness, and built one of the first functional medicine practices in the country — alongside Jeff Bland, the father of functional medicine.
After producing 12 documentary series — including Interconnected — seen by millions worldwide, he came back to medicine for one reason: the gap between what the science knows and what patients are actually receiving was unconscionable.
Today he oversees a network of doctors in all 50 states, is a keynote speaker at the two largest dental conferences in the country, and is actively publishing research on the oral-systemic connection — the next frontier in medicine.
What's in This Masterclass
90 Minutes of Science They Never Taught You
Why You're Still Struggling
The conventional medical model is caught in a downstream trap — chasing symptoms while the root cause continues to rage. Dr. Shojai explains why this isn't your fault, and why the system is designed to keep you coming back.
Endotoxemia: The Silent Killer
LPS — lipopolysaccharide — is a bacterial toxin that leaks through a damaged gut wall and triggers systemic inflammation. It is now implicated in virtually every chronic disease in modern humans, and almost no one is testing for it.
The Gut-Brain Axis Under Attack
The science linking gut dysbiosis to anxiety, depression, brain fog, and insomnia is overwhelming and unambiguous. The gut produces 90% of your serotonin. When it's compromised, your mind pays the price.
The Cardiovascular Connection
The newest research is showing that most cardiovascular disease is immunologically triggered — and those immune triggers originate at the gut lining and the gums. This is the next frontier in medicine.
Food Sensitivities & Autoimmunity
IgG and IgA mediated food responses drive gut dysbiosis, intestinal permeability, and downstream autoimmunity. The foods you eat every day may be the source of your inflammation — and an elimination protocol can prove it.
Precision Microbiome Medicine
Taking generic acidophilus for everything is like prescribing aspirin for every pain. Targeted bacterial strains and specific botanicals — matched to your actual microbiome data — produce entirely different results.
The 6R Protocol
Remove, Replace, Reinoculate, Repair, Rebalance, Retain. The exact 6-week framework used by functional medicine practitioners worldwide — now available as a structured, guided course.
Vetting the Science
Not all studies are created equal. Dr. Shojai explains how to evaluate research quality — sample size, replication, funding transparency — and why this matters more than who's talking loudest on Instagram.
"If you don't swim upstream, you're never actually going to get better. You're not going to get healed if you don't go to the root cause and you're playing whack-a-mole with symptoms."
— Dr. Pedram Shojai
Ready to Go Deeper?
The Masterclass Was the Map.
The Course Is the Journey.
Watching a masterclass doesn't change your gut. Having a structured, personalized, science-backed protocol — and the tools to follow it — does. Dr. Shojai built the Upstream course and app because nothing like it existed.
What the course and app give you that no documentary can:
Choose Your Path Upstream
All three paths include a certified health coach consultation and the 30-Day Gut Reset Promise.
Path 1: The Test
For the Analyst Who Needs to See the Data.
You trust what you can measure. You want to see the evidence, connect the dots for yourself, and build a plan based on hard data — not just intuition.
What You Get:
- ✓KBMO FIT22 Food Sensitivity Test — at-home blood spot test identifying your immune reactions to the 22 most common food sensitivities.
- ✓Gut Barrier Permeability Panel — tests for zonulin, occludin, LPS, and candida to confirm whether your gut barrier is compromised.
- ✓Private 30-Minute Health Coach Call — a certified coach walks you through exactly what your results mean and what to do next.
Price
Normally $299
$199One-time payment. Kit ships to your door.
Path 2: The Course
For the Self-Starter Who Wants a Proven Framework.
You're motivated and ready to act. You want a comprehensive, step-by-step system you can trust — built by the world's leading experts in functional gut health.
What You Get:
- ✓The Complete Upstream Course — the full 6-week, 42-lesson 6R Framework with Dr. Pedram Shojai and Dr. Jeff Bland.
- ✓6 Downloadable Workbooks — weekly field guides with checklists, tracking tools, and action plans.
- ✓Exclusive Dr. Jeff Bland Masterclass Modules — direct teaching from the Father of Functional Medicine.
- ✓The Full Interconnected Docu-Series — all 10 episodes plus the complete bonus library.
- ✓Lifetime Access — revisit the lessons and receive all future updates at no extra cost.
Price
Normally $399
$299One-time payment. Instant access.
Already have testing? This is your path.
Get the Course →Path 3: The Upstream Bundle
The Complete System: Test, Learn, and Heal.
Everything in Paths 1 and 2 — combined into one complete clinical system. Get your personal data, follow the exact protocol to fix what the data reveals, and have a certified coach guide you every step of the way.
What You Get:
- ✓KBMO FIT22 Food Sensitivity Test — clinical-grade at-home blood spot test.($199 value)
- ✓Gut Barrier Permeability Panel — tests for zonulin, occludin, LPS, and candida.($150 value)
- ✓The Complete Upstream Course — the full 6-week, 42-lesson 6R Framework.($299 value)
- ✓Exclusive Dr. Jeff Bland Masterclass Modules — direct teaching from the world's foremost authority on functional gut health.($497 value)
- ✓The Full Interconnected Docu-Series — all 10 episodes plus the Director's Cut and complete bonus library.($497 value)
- ✓6 Downloadable Workbooks — weekly field guides with checklists and action plans.($97 value)
- ✓Private 1-on-1 Health Coach Call — a certified functional medicine health coach builds your exact action plan.($250 value)
- ✓Lifetime Access + All Future Updates — revisit the protocol and receive every new lesson at no extra cost.
What You'd Pay Separately
Get everything for just $399.
Price
Normally $498
$399One-time payment. Kit ships to your door + instant digital access.
🔒 Secure checkout · 30-Day Gut Reset Promise · HSA/FSA eligible — email us for the link
Common Questions
The Information Should Be at Your Fingertips.
Watching the series was a start. The tools exist to go further — to test, to know, and to actually fix what's happening in your gut. The only question is whether you're ready to use them.